Dr. Ariane Kwiet, MD, PhD
Multiple osteochondromas (MO) and Ollier disease (OD) are to rare diseases that feature benign tumors in the skeletal bones. Common complications are bone deformity, restricted joint motion, interference with skeletal growth and risk for malign transformation. A large part of the literature focuses on genetics or surgical interventions. Recently, however, some studies suggested that chronic pain and fatigue is a problem in these diseases.
This systematic review has three main goals: a) present existing research on chronic pain and fatigue in MO and OD patients, b) make clinicians aware of current knowledge on fatigue and chronic pain c) identify gaps and topics for future research.
We conducted a systematic search in the following databases: MEDLINE (Ovid), Embase (Ovid), APA PsycInfo (Ovid), CINAHL (EBSCO), Science Citation Index Expanded (Web of Science). We included studies examining children and/ or adults with either MO or OD and where chronic pain and/ or fatigue is part of the assessment. From the included studies, we will extract information on study background, patients, pain and fatigue (prevalence, type, intensity, duration, treatment and assessment tools). We will also assess study quality and focus on future research targets.
Results of this review can be used in treatment guidelines and shall be used as a basis for a future study about chronic pain and fatigue in these diagnoses.
Not applicable
No extern founding.
Desember 2022 – July 2024
