6MWT - 6 minutter gangtest

Hjern​​eslag

Standardfeilen (SEM: Standard Error of Measurement):

• Kronisk hjerneslag: 12.4m (Eng et al., 2004)
• Kronisk hjerneslag (utendørs) 11.9m (Wevers et al., 2011)
• Hjerneslag (GPS) 18.1m (Wevers et al., 2011)
• Kvinne med kronisk hjerneslag: 18.6m (Flansbjer et al., 2005)
• Generelt: 11.9 – 23.2m (Machiavelli et al., 2020)

Minste målbare endring (MDC: Minimum Detectable Change):

• Subakutt hjerneslag : 61m (60.96m)?
• Kronisk hjerneslag: 43m (42.98m)
• Kronisk ryggskade: 46m (45.72m)
• Kronisk hjerneslag: 34.4m (Eng et al., 2004)
• Kronisk hjerneslag: 36.6m (Flasbjer et al., 2005)
• Subakott hjerneslag: 61.0m (Perera et al., 2006)

Minste klinisk relevante endring (MICD: Minimal Clinically Important Difference):

• Subakutt hjerneslag - liten endring: 20m (20.12m)
• Subakutt hjerneslag - betydelig endring: 50m (49.99)
• Kronisk hjerneslag: 34.4m
• Post-hjerneslag (2-6mnd), evne til gå 3 m med < maks assistanse, (Fulk 2018). (Fulk & He 2018):
• når initial ganghastighet <0,40 m / s = 44 m17
• når første ganghastighet ≥0,40 m / s = 71 m17

Reliabilitet​​​:

Test-retest reliabilitet: ICC - 0.98 (95%IC), (Eng et al., 2004, Flasberg et al., 2005, Fulk et al., 2oo8, Liu et al., 2008, Wever, et al., 2011 & Macchiavelli et al., 2020)

Interrate/intrarate reliability: ICC - 0.78 and 0.75 (Kosak & Smith 2005, Macchiavelli et al., 2020)

Kriterier/validitet (prediksjon​​/simutant):

• Kronisk hjerneslag (Flasbjer et al., 2005)

Validitet: TUG:r=0.89
10 meters gangtest med behagelig ganghastighet: r=0.84
10 meters gangtest med rask ganghestighet: r=0.94
Trappeklatring: r=0.82
Trappenedstigning: r=0.80

• Akutt hjerneslag (Kosak & Smith 2005)

Korrelasjon med
2 minutters gangtest: r=0.997
12 minutters gangtest: r=0.994

• Kronisk hjerneslag (Wevers et al., 2011)

Validitet ved første test utendørs: GPS og målehjul: r=0.98, p<0.000
Ved andre test utendørs: GPS og målehjul: r=0.99, p<0.000

Resp​​ons:

Standarizes Respons Means (SRM): 1.52 (Kosak & Smith 2005).

Lungesykdommer

Minste målbare endring (MDC:Minimum Detectable Change): 54 m (Redelmeier et al., 1997)

Minste klinisk relevante endring (MICD:Minimal Clinically Important Difference): 54 m Resekaba et al,. 2009)

N​​ormati​​ve data:

• Gjennomsnittlig gangavstand 380 m: range 160-660 m (Cassanova et al., 2007, & Szekely et al., 1997)
• Avstand < 200 m = prediktiv for sykehusinnleggelse eller dødelighet

Criterion validity​​ (predictive/​​concurrent):

• Manglende evne til å gå > 45: De beste prediktorene for uakseptabel postoperativ utfall og dødelighet (spesifisitet = 84%, sensitivitet = 82%) (szekely et al., 1997)

Tilstrekkelig korrelasjon m​ed lengde på s​​ykehusopphold:

• Pre-kirurgisk 6MWT: r=0.32
• Post-kirurgisk 6MWT: r=0.04

Res​​pons​​:

• Demonstrerer betydelig nedgang hos personer med alvorlig luftveisobstruksjon (Cassanove et al., 2007)
• Nedgang forverres med sykdommens alvorlighets

Parkinsons sykdom

Minste målbare endring (MDC: Mininum Detectable Change):

• 82 m (Steffen & Senney 2008, Steffen et al., 2008, Yahr 1-4, median 2)

Reli​ab​​ility:

• Test-retest: ICC = 0.95 - 0.96 (Steffen T, Seney 2008

Ryggmargskade

Standard Error of Measurement (SEM):

• 16.5 m (vanHedle et al., 2005, Lam et al., 2008).

Minste målbare endring (MDC: Minimum Detectable Change):

• 45m (Lam et al., 2008).

Minste klinisk relevante endring (MICD: Minimal Clinically Important Difference):

• Overall: 0.10 m/s
• Slow: 0.11 m/s (Forrest et al., 2014)

Reliabilitet:

• Inter/intra-rate: ICC – 0.99 (Scivoletto et al., 2011).
• Inter-rate: r = 0.97 (vanHedel et al., 2005).

Alzheimer's sykdom

Standard Error of Measurement (SEM):

• mild til moderat: 21.86 m
• moderat alvorlig til alvorlig: 19.57 m (Ries et al., 2009).

Minste målbare endring (MDC: Minimum Detectable Change):

• 33.47 m (Ries et al., 2009).

Reliabilitet:

• Test-retest: ICC = 0.98 – 0.99 (Ries et al., 2009).
• Inter-rate: ICC = 0.98 – 0.99 (Tappen et al., 1997)
• Intra-rate: ICC = 0.76 – 0.90 (Tappen et al., 1997)

Eldre voksne og eldreomsorg

Standard Error of Measurement (SEM):
Eldre med hjerneslag: (Perera et al., 2006).

• styrke treningstest: 21m
• intervensjonstest: 22m

Minste målbare endring (MDC: Minimum Detectable Change):

• 58 m (Perera et al., 2006).

Minste klinisk relevante endring (MICD: Minimal Clinically Important Difference):

• Eldre med hjerneslag: 50m (Perera et al., 2006)

Normativ endring:
Eldre hjemmeboende (Steffens et al., 2002)

Reliabilitet:

• Test-retest: r = 0.95 (Harada et al., 1999)
• Test-retest: r = 0.95 (Stepehn et al., 2002)

Responsiveness (responsiv?):

• Liten endring: 20 m
• Signifikant endring: 50 (Perera et al., 2002).

Multippel sklerose (MS): mean Expaned Disability Status Scale (EDSS) = 3.5)

• 88m or 20% change 10 (Learmonth et al., 2013)

Osteoartitt

Standard Error of Measurement (SEM):

• 26.29 m (Kennedy et el., 2005)

Minste målbare endring (MDC: Minimum Detectable Change):

• 61.34 m ((Kennedy et el., 2005)

Reliabilitet:

• Test-retest: ICC = 0.93 (Kennedy et el., 2005)

Hjerneskade

Reliabilitet

• Test-retest: ICC=0.94 (Mossberg et al., 2003)
• Test-retest: ICC=0.94 (VanLoo et al., 2004)

Huntingtons sykdom (HD: Huntington Disease)

Minste målbare endring (MDC: Minimum Detectable Change):

• pre-manifest: 39.2 m1 (Quinn et al., 2013).
• manifest: 86.6 m1
• tidlig-fase: 56.6 m1
• midt-stadie: 126.14 m1
• senstadie: 70.7 m1

Reliabilitet
Test-retest pålitelighet

• pre-manifest: ICC = 0.98 (Quinn et al., 2013).
• manifest: ICC = 0.94
• tidlig stadiet: ICC = 0.97
• midt-stadiet: ICC = 0.86
• sen-stadiet: ICC = 0.97

https://pubmed.ncbi.nlm.nih.gov/29901487/

https://neuropt.org/practice-resources/anpt-clinical-practice-guidelines/core-outcome-measures-cpg

FYSIOPRIM prosjektet ved UiO beskriver 6MWT i sammenheng med andre verktøy

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